The Sleep and Circadian Neurobiology Laboratory

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An integrated, multidisciplinary research facility dedicated to...

understanding sleep-wake control and biological rhythms at all levels from the molecular to the behavioral, and
developing new generations of pharmaceuticals to remedy the enormous unmet needs of sleep disorders medicine and disorders of circadian timekeeping.

The SCN Lab has developed a number of model systems and special resources for research and testing, including...

A large scale sleep-wake and circadian rhythm bioassay facility
Automated data tracking and analysis computers to assure rapid, accurate communication of experimental results to research sponsors
Unique animal model systems include a narcoleptic rodent colony for testing alerting pharmacological agents and other genetically engineered mouse models, such as a murine model of human short sleeper (i.e., DEC2-P385R TG mice).
Pharmacology in sleep deprived animals
MPEG video monitoring system synchronized with EEG signals
In vivo microdialysis and HPLC analysis for neurotransmitter and regional drug delivery studies together with sleep monitoring
Neurochemical assessments, such as radio receptor bindings/gamma GTP- binding and radio/enzyme-immuno assays and analysis of gene expressions (quantitative RT-PCR)
Molecular biology laboratory